Studies have shown that the effects of early-life stress and trauma can be enduring, with long-term negative effects on health.Epigenetics, including DNA methylation, have been implicated as a potential mechanism for these effects.Brain-derived neurotropic factor (BDNF) is a neurotransmitter involved in learning and memory, and Vanity and Mirror al

Continuous exposure of tissue antigen (Ag) to the autoantigen-specific regulatory T cells (Treg) is required to maintain Treg-dependent systemic tolerance.Thus, testis autoantigens, previously considered as sequestered, may not be protected by systemic tolerance.We now document that the complete testis antigen Gardening Stool sequestration is not v